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Concomitant use of penicillins may decrease renal clearance of methotrexate by inhibiting renal tubular secretion amoxicillin. Carefully monitor patients receiving methotrexate and penicillins concomitantly.
Oral probenecid administered shortly before or simultaneously with aminopenicillins slows the rate of renal tubular secretions of penicillins and produces higher and prolonged serum concentrations of the drugs.
Allopurinol may increase the possibility of skin rash, particularly in hyperuricemic patients.
Concomitant use of penicillins with oral contraceptives may cause breakthrough bleeding.
