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Lactic acidosis is a rare, but serious metabolic complication that can occur due to Metformin hydrochloride accumulation. The reported incidence of lactic acidosis during Metformin hydrochloride treatment is lower than 0.1 case per 1000 patient-years, and the mortality risk is even lower.
Lactic acidosis is a medical emergency that must be treated in a hospital setting. In a patient with lactic acidosis, the drug should be discontinued immediately and general supportive measures promptly instituted.
