Ova-Mit Mechanism of Action

Pharmacotherapeutic group: ovulation stimulants synthetic. ATC code: G03BG02.
Pharmacology: Pharmacodynamics: Mechanism of Action: The ovulatory response to cyclic Ova-Mit tablets therapy is mediated through increased output of pituitary gonadotrophins, which in turn stimulates the maturation and endocrine activity of the ovarian follicle.
Pharmacodynamic effects: Ova-Mit is a triarylethylene compound (related to Chlorotrianisene and Triparanol). It is a non-steroidal agent which stimulates ovulation in a high percentage of appropriately selected anovulatory women. Clomifene Citrate has mainly antiestrogenic effects and some estrogenic effects.
Pharmacokinetics: Orally administered ¹⁴C labelled Clomifene Citrate in humans was readily adsorbed. Cumulative excretion of the ¹⁴C label by way of urine and faeces averaged about 50% of the oral dose after 5 days in 6 subjects, with mean urinary excretion of 7.8% and mean faecal excretion of 42.4%. A mean rate of excretion of 0.73% per day of the ¹⁴C dose after 31 days to 35 days and 0.45% per day of the ¹⁴C dose after 42 days to 45 days was seen in faecal and urine samples collected from 6 subjects for 14 to 53 days after Clomifene Citrate ¹⁴C administration. The remaining drug/metabolites may be slowly excreted from a sequestered enterohepatic recirculation pool.