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Use in Pregnancy: Category D: Zoledronic acid should not be used during pregnancy. Although no data exists on fetal risk in humans, bisphosphonates are incorporated into the bone matrix and is gradually released over a period of years. This may theoretically cause serious skeletal malformation when a fetus is exposed to zoledronic acid.
Use in Lactation: It is not known whether zoledronic acid is excreted in human milk. Since many drugs are excreted in human milk and because zoledronic acid binds to bone long term, zoledronic acid should not be used by breastfeeding women.
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