Numetrax Dosage/Direction for Use

Adults and children over twelve years: 1-2 grams of Ceftriaxone sodium is administered once daily intravenously or intramuscularly. In severe cases or infections caused by moderately sensitive organisms, the dosage may be increased up to 4 g once daily.
Neonates (up to 14 days): A daily dose is 20-50 mg/kg bodyweight not to exceed 50 mg/kg. It is not necessary to differentiate between premature and infants born at term.
Infants and children (15 days to twelve years): A daily dose of 20-80 mg/kg for children of 50 kg bodyweight or more, the usual adult dosage should be used. Intravenous dose if 50 mg or more per kg bodyweight should be given by infusion over at least 30 minutes. The recommended dosage for adults.
Elderly patients: The dosages recommended for adults require no modification in the case of geriatric patients.
Meningitis: In bacterial meningitis in infants and children, treatment begins with doses of 100 mg per kg (not to exceed 4 g) once daily. As soon as the causative organism has been identified and its sensitivity determined, the dosage can be reduced accordingly, The following duration of therapy has shown to be effective. (See table.)

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Gonorrhea: for the treatment of gonorrhoea (penicillinase-producing and non penicillinase-producing strains), a single I.M. dose of 250 mg is recommended.
Perioperative and postoperative prophylaxis: To prevent postoperative infection in contaminated or potentially contaminated surgery. The recommended approach-depending on the risk of infection is a single dose of 1-2 grams administered 30-90 minutes prior to surgery in colorectal surgery. In colorectal surgery, concurrent (but separately administered) administration of the drug with a 5-nitroimidazole (e.g. ornidazole) has proven effective.
Impaired renal and hepatic function: In patients with impaired renal function, there is no need to reduce the dosage of Ceftriaxone provided hepatic function is intact. But in case of preterminal renal failure (creatinine clearance < 10 ml/min) the dosage should not exceed 2 g daily. In patients with liver damage, there is no need for the dosage to be reduced if renal function is intact. In cases of combined severe renal function and hepatic dysfunction, the plasma concentrations of Ceftriaxone should be determined at regular intervals. In patients undergoing dialysis, no additional supplementary dosing is required in the dialysis. Serum concentrations should be monitored. However, to determine whether dosage adjustment is necessary, Since the elimination rate in these patients may be reduced.
Duration of Therapy: The duration of therapy varies according to the recovery from the disease. As with antibiotic therapy in general, administration of the drug should be continued for a minimum of 48 to 72 hours after the patient has become afebrile or evidence of bacterial eradication has been obtained.
Preparation of Injectable Solution: Intramuscular injection: I.M. injection, 0.25 g or 0.5 g is dissolved in 2 ml, and 1 g in 3.5 ml of 1% Lidocaine Hydrochloride Solution and injected well within the body of a relatively large muscle. It is recommended that not more than 1 g is injected at one site I.M. injection without Lidocaine Solution is painful. The Lidocaine Solution must never be administered intravenously. Intravenous injection: For I.V. injection, 0.25 g or 0.5 g is dissolved in 5 ml, and 1 g in 10 ml Sterile Water for Injection. The intravenous administration should be given over two or four minutes. In case of intravenous infusion, the infusion should last at least 30 minutes. For I.V. infusion, 2 g are dissolved in 40ml of one of the following calcium-free infusion solutions; Sodium Chloride 0.9% , Sodium Chloride 0.45% + Dextrose 2.5% , Dextrose 5%, Dextrose 10%, Dextran 6% in Dextrose 5%, Hydroxy ethyl starch 6~10% infusions and Sterile Water for Injection. The solutions should not be mixed with our piggybacked into solutions containing other antimicrobial drugs or into diluent solutions other than those listed mentioned previously, owing to possible incompatibility. Reconstituted solutions retain their physical and chemical stability for six hours at room temperature of 24 hours at +5˚C. As general rule, However, the solutions should be used immediately after preparation. They range in colour from pale yellow to amber, depending on the concentration and the length of storage. This characteristic of the active ingredient is of no significance for the efficacy or tolerance of the drug. This is for single use only, discard any remaining portion.