Adult & childn <12 yr 1-2 g once daily IV or IM. Severe cases/infection caused by moderately sensitive organism Max: 4 g once daily. Perioperative & post-op prophylaxis Single dose of 1-2 g administer 30-90 min prior to colorectal surgery. Gonorrhea IM single dose of 250 mg. Preterminal renal failure (CrCl <10mL/min) Max: 2 g daily. Childn (12 yr) & infant (15 days) 20-80 mg/kg daily; >50 kg 50 mg IV infusion over at least 30 min. Neonates ≤14 days Daily dose 20-50 mg/kg. Max: 50 mg/kg. Meningitis 100 mg/kg. Max: 4 g once daily.
History of drug allergy. Allergic symptoms eg, bronchial asthma, exanthema, urticaria. Poor oral or parenteral nutrition; poor general conditions. Severe renal disorder. Pregnancy & lactation. Elderly.
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