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The administration of single IM doses of 72 mg of Nubain to 8 normal subjects has been reported to have resulted primarily in symptoms of sleepiness and mild dysphoria.
Naloxone HCl is a specific antidote for nalbuphine HCl, but symptomatic and supportive therapy will usually suffice for mild or moderate overdosage. Oxygen, IV fluids, vasopressors and other supportive measures should be employed as indicated.
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