NovoMix 30 FlexPen Caution For Usage

Incompatibilities: In absence of compatibility studies, biphasic insulin aspart 30 must not be mixed with other medicinal products.
Instructions on How to Handle Biphasic Insulin Aspart 30: Before Using FlexPen: Check the label to make sure it is the right type of insulin.
Always use a new needle for each injection to prevent contamination.
Do not use biphasic insulin aspart 30 in insulin infusion pumps; if the flexpen is dropped, damaged or crushed, there is a risk of leakage of insulin; if it hasn't been stored correctly or if it has been frozen; if the insulin is not uniformly white and cloudy when it's resuspended; if clumps of material are present or if solid white particles stick to the bottom or the wall of the cartridge giving a frosted appearance.
Biphasic insulin aspart 30 is for injection under the skin (SC). Never inject the insulin directly into a vein or muscle.
Always vary the sites to inject, to avoid lumps or skin pitting. The best places to give an injection are: Front of the waist (abdomen); buttocks; front of the thighs or upper arms. The insulin will work more quickly if injected around the waist. Measure blood sugar regularly.
Biphasic insulin aspart 30 is a unique dial-a-dose insulin pen. Dose from 1-60 U in increments of 1 can be selected. Flexpen is designed and tested to be used with NovoFine disposable needles up to a length of 8 mm. As a precautionary measure, always carry a spare insulin device in case biphasic insulin aspart 30 is lost or damage.
Preparing Biphasic Insulin Aspart 30 FlexPen: Check the label to make sure that it contains the correct type of insulin. Before the 1st injection with a new biphasic insulin aspart 30, the insulin must be resuspended: Let the insulin reach room temperature before using to make it easier to resuspend. Pull off the pen cap. Roll the pen between the palms 10 times. It is important that the pen is kept horizontal. Then move the pen up and down 10 times between the 2 positions so the glass ball moves from 1 end of the cartridge to the other. Repeat rolling and moving the pen until the liquid appears uniformly white and cloudy. For every following injection, move the pen up and down between the 2 positions at least 10 times until the liquid appear uniformly white and cloudy. After having resuspended the insulin, complete all the following steps of injection without delay.
Always check if there are at least 12 U of insulin left in the cartridge to allow resuspension. If there are <12 U left, use a new FlexPen.
Attaching a Needle: Remove the protective tab from a new disposable needle. Screw the needle straight and tight onto biphasic insulin aspart 30. Pull off the big outer needle cap and keep it for later. Pull off the inner needle cap and dispose of it.
Always use a new needle for each injection to prevent contamination. Be careful not to bend or damage the needle before use. To reduce the risk of unexpected needle sticks, never put the inner needle cap back on when removing it from the needle.
Checking the Insulin Flow: Prior to each injection, small amount of air may collect in the cartridge during normal use. To avoid injection of air and ensure proper dosing: Turn the dose selector to select 2 U. Hold biphasic insulin aspart 30 with the needle pointing upwards and tap the cartridge gently with a finger a few times to make any air bubbles collect at the top of the cartridge. Keeping the needle upwards, press the push button all the way in. The dose selector returns to 0. A drop of insulin should appear at the needle tip. If not, change the needle and repeat the procedure no more than 6 times. If a drop of insulin still does not appear, the pen is defective and a new one must be used.
Selecting the Dose: Check that the dose selected is set to 0. Turn the dose selector to select the number of units needed to inject. The dose can be corrected either up or down by turning the selector in either directions until the correct dose lines up with the pointer. When turning the dose selector, be careful not to push the push-button as insulin will come out. A dose larger than the number of units left in the cartridge cannot be selected.
Do not use the residual scale to measure the dose of insulin.
Making the Injection: Insert the needle into the skin. Use the injection technique shown by the doctor or nurse. Inject the dose by pressing the push-button all the way in until 0 lines up with the pointer. Be careful only to push the push-button when injecting. Turning the dose selector will not inject insulin. Keep the push-button fully depressed and let the needle remain under the skin for at least 6 sec. This will ensure that the full dose has been injected. Withdraw the needle from the skin, then release the pressure on the push-button. Lead the needle tip into the big outer needle cap without touching the big outer cap. When the needle is covered, carefully push the big outer needle cap completely on and then unscrew the needle. Dispose of it carefully and put the pen cap back on.
Always remove the needle after each injection and store biphasic insulin aspart 30 without the needle attached. Otherwise, the liquid may leak out which can cause inaccurate dosing. Caregivers should be most careful when handling used needles to avoid needle sticks. Dispose of the FlexPen carefully without the needle attached. Do not share biphasic insulin aspart 30 with anyone else.
Maintenance: Biphasic insulin aspart 30 is designed to work accurately and safely. It must be handled with care. If it is dropped or crushed, there is a risk of damage and leakage of insulin.
Clean the exterior biphasic insulin aspart 30 by wiping it with a medicinal swab. Do not soak, wash or lubricate it as it may damage the pen.
Do not refill biphasic insulin aspart 30.
Instructions on Disposal and Other Handling: Biphasic insulin aspart 30 must not be shared. The cartridge must not be refilled.
Biphasic insulin aspart 30 must not be used if the resuspended liquid does not appear uniformly white and cloudy. The necessity of resuspending the biphasic insulin aspart 30 suspension immediately before use is to be stressed to the patient.
Biphasic insulin aspart 30 which has been frozen must not be used. The patient should be advised to discard the needle after each injection.