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ACE inhibitors should not be used during pregnancy. When pregnancy is diagnosed, immediately discontinue treatment with ACE inhibitors, and, if appropriate, alternative treatment should be started.
Thiazides cross the placenta, and use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice, thrombocytopenia and possibly other adverse reactions that have occurred in adults.
Lactation: Imidapril, as with other ACE inhibitors, may be excreted in human milk. Thiazides appear in human milk. Discontinue breastfeeding or drug due to potential risk to breastfeeding infants, taking into consideration the importance of the drug to the mother.
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