Norplus Adverse Reactions

Imidapril hydrochloride: Infections and infestations: Viral infection.
Blood and lymphatic system disorders: Agranulocytosis, anemia, leukopenia, neutropenia, pancytopenia, thrombocytopenia; individual cases of hemolytic anemia in patients with congenital deficiency of glucose-6-phosphate dehydrogenase (G6PD) have been reported with other ACE inhibitors.
Metabolism and nutrition disorders: Anorexia, hyperkalemia, hypoglycemia, thirst.
Psychiatric disorders: Depression, insomnia, sleep disorders, sleepiness.
Nervous system disorders: Cerebral hemorrhage, cerebrovascular disorders, confusion, disorder of balance, dizziness/postural dizziness, dysgeusia, headache, lightheadedness, paresthesia, somnolence, syncope, taste disturbance.
Eye disorders: Blurred vision.
Ear and labyrinth disorders: Tinnitus.
Cardiac disorders: Angina pectoris, arrhythmia, myocardial infarction, palpitations, tachycardia.
Vascular disorders: Severe hypotension after initiation of therapy or increase of dose; dizziness, feeling of weakness, impaired vision, and disturbance of consciousness (syncope) can also occur in association with hypotension; facial flushing, transient ischemic attack.
Respiratory, thoracic and mediastinal disorders: Cough, allergic alveolitis/eosinophilic pneumonia (very rare), angioedema involving the upper airways, bronchitis, bronchospasm, dyspnea, glossitis, hoarseness, pharynx discomfort, rhinitis, sinusitis, upper respiratory tract infection.
Gastrointestinal disorders: Abdominal pain, constipation, diarrhea, dry mouth, dyspepsia, epigastric pain, gastritis, ileus, intestinal angioedema, nausea, pancreatitis, queasy, stomach discomfort, vomiting.
Hepatobiliary disorders: Cholestatic icterus, hepatitis, jaundice.
Skin and subcutaneous tissue disorders: Allergic and hypersensitivity reactions such as rash, pruritus, exanthema, and urticaria; angioneurotic edema involving the face and oropharyngeal tissues; cutaneous symptoms accompanied by fever, myalgia, arthralgia, eosinophilia and/or increased antinuclear antibody (ANA) titers; alopecia, erythema multiforme, exfoliative dermatitis, pemphigus-like symptoms, photosensitivity reactions, psoriasis-like efflorescences, Stevens-Johnson syndrome, toxic epidermal necrolysis, blisters.
Renal and urinary disorders: Acute renal failure, aggravation of renal function disorder, renal impairment, proteinuria.
General disorders and administration site conditions: Chest discomfort, chest pain, edema (joint, peripheral), fatigue, feeling of weakness, malaise, numbness, pain in limbs, weariness.
Reproductive system and breast disorders: Impotence.
Investigations: Increased blood amylase, blood urea nitrogen, plasma creatinine, serum potassium, liver enzymes, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), γ-glutamyl transpeptidase (γ-GTP), serum bilirubin, creatine phosphokinase (CPK), eosinophil; decreased albumin, serum protein, erythrocyte, thrombocyte, leukocyte, hemoglobin, hematocrit, platelets, white blood cell count.
Hydrochlorothiazide: Neoplasms benign, malignant and unspecified (including cysts and polyps): Non-melanoma skin cancer (basal cell carcinoma and squamous cell carcinoma).
Blood and lymphatic system disorders: Agranulocytosis, aplastic anemia, bone marrow failure, granulocytopenia (rare), hemolytic anemia, leukopenia, neutropenia, thrombocytopenia.
Immune system disorders: Hypersensitivity reactions, anaphylactic reactions.
Endocrine disorders: Worsening of diabetic control.
Metabolism and nutrition disorders: Anorexia, decreased appetite, electrolyte imbalance, hypercalcemia, hypercholesterolemia, hyperglycemia, hyperuricemia, hypochloremic alkalosis, hypokalemia, hypomagnesemia, hyponatremia, hypophosphatemia, hypovolemia.
Psychiatric disorders: Insomnia, nervousness.
Nervous system disorders: Cephalgia, dizziness, headache, lightheadedness, paresthesia, restlessness, vertigo .
Eye disorders: Acute myopia, secondary angle-closure glaucoma, transient blurred vision, visual impairment, xanthopsia.
Cardiac disorders: Cardiac arrhythmias.
Vascular disorders: Hypotension/orthostatic hypotension.
Respiratory, thoracic and mediastinal disorders: Respiratory distress (including pneumonitis and pulmonary edema).
Gastrointestinal disorders: Constipation, cramping, diarrhea, gastric irritation, gastrointestinal discomfort, nausea, pancreatitis, sialadenitis, spasms, vomiting.
Hepatobiliary disorders: Jaundice (intrahepatic cholestatic jaundice).
Skin and subcutaneous tissue disorders: Alopecia, cutaneous lupus erythematosus, erythema multiforme including Stevens-Johnson syndrome, exfoliative dermatitis including toxic epidermal necrolysis, necrotizing angiitis (vasculitis and cutaneous vasculitis), photosensitivity reactions, purpura, rash, reactivation of cutaneous lupus erythematosus, urticaria.
Musculoskeletal and connective tissue disorders: Muscle cramps, muscle spasm.
Renal and urinary disorders: Glycosuria, interstitial nephritis, renal dysfunction, renal failure.
Reproductive system and breast disorders: Impotence.
General disorders and administration site conditions: Asthenia, fever, weakness.
Investigations: Increased total cholesterol, low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C) and triglycerides.