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Pharmacology: Pharmacokinetics: Peak plasma-pantoprazole concentrations are achieved about 2 to 2.5 hours after an oral dose.
The oral bioavailability is about 77% with the enteric-coated formulation, and dose does not vary after single or multiple doses. Pantoprazole is 98% bound to plasma proteins. It is extensively metabolized in the liver, primarily by the cytochrome P450 isoenzyme CYP2C19, to desmethylpantoprazole; small amounts are also metabolized by CYP3A4, CYP2D6, and CYP2C9.
Metabolites are excreted mainly (about 80%) in the urine, with the remainder being excreted in the bile. The terminal elimination half-life is about 1 hour, and is prolonged in hepatic impairment; the half-life in patients with cirrhosis was 3 to 6 hours.
