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Each tablet contains sorafenib 200 mg (sorafenib tosylate 274 mg).
Nexavar also contains the following excipients: Tablet Core: Croscarmellose sodium, microcrystalline cellulose, hydroxypropylmethyl cellulose, sodium lauryl sulfate magnesium stearate. Film-Coating: Hydroxypropylmethyl cellulose, macrogol, titanium dioxide, red iron oxide
Sorafenib tosylate is 4-(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]-ureido}phenoxy)-N2-methylpyridine-2-carboxamide 4-methylbenzenesulfonate. Its empirical formula is C21H16ClF3N4O3 x C7H8O3S and molecular weight is 637 g/mole.
Sorafenib tosylate is a white to yellowish or brownish solid. It is practically insoluble in aqueous media, slightly soluble in ethanol and soluble in PEG 400.
