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Probenecid causes an almost 2-fold reduction in clearance of paracetamol by inhibiting its conjugation with glucuronic acid. A reduction in the paracetamol dose should be used concomitantly with probenecid.
Salicylamide may prolong the elimination ½ life of paracetamol.
Caution should be taken with the concomitant intake of enzyme-inducing substances.
Concomitant use of paracetamol (4 g per day for at least 4 days) with oral anticoagulants may lead to slight variation of INR values.
In this case, increased monitoring of INR values should be conducted during the period of concomitant use as for 1 week after paracetamol treatment has been discontinued.
