Newpamol Dosage/Direction for Use

Intravenous use: The 100 mL vial is restricted to adults, adolescent and children weighing more than 33 kg (approximately 1 year old).
Dosage: Adolescent and adults weighing more than 50 kg: Paracetamol 1 g per administration, i.e., 1.5 mL solution per kg up to four times a day. The minimum interval between each administration must be 4 hours. The maximum daily dose must not exceed 4 g.
Children weighing more than 33 kg (approximately 11 years old), adolescent and adults weighing less than 50 kg: Paracetamol 15 mg/kg per administration, i.e., 1.5 mL solution per kg up to four times a day. The minimum intervals between each administration must be 4 hours. The maximum daily dose must not exceed 60 mg/kg (without exceeding 3 g).
Children weighing more than 10 kg (approximately 1 year old), and weighing less than 33 kg: Paracetamol 15 mg/kg per administration, i.e., 1.5 mL solution per kg up to four times a day. The minimum intervals between each administration must be 4 hours. The maximum daily dose must not exceed 60 mg/kg (without exceeding 2 g).
Term newborn daily infants, toddlers and children weighing less than 10 kg (up to approximately 1 year old): Paracetamol 7.5 mg/kg per administration, i.e., 0.75 mL solution per kg up to four times a day. The minimum intervals between administration must be 4 hours. The maximum daily dose must not exceed 30 mg/kg. No safety and efficacy data for premature neonates.
The paracetamol solution is administered as a 15-minute intravenous infusion. Paracetamol 50 mL vial can also be diluted in a 0.9% sodium chloride solution up to one tenth. In this case, use the diluted solution within the hours following its preparation (infusion time included). As for all solutions for infusion presented in glass vials, it should be remembered that close monitoring at the end of the infusion applies particularly for central route infusion, in order to avoid air embolism.
Severe Insufficiency: It is recommended, when giving paracetamol to patients with severe renal impairment (creatinine clearance 30 mL/min), to increase the minimum intervals between each administration to 6 hours.