Concomitant administration of calcium-containing drugs may cause or aggravate elevated serum calcium levels.
Uraemic symptoms improve under therapy with Nephrotor. Thus, in case of aluminium hydroxide administration, the dose of this drug needs to be reduced if necessary. Serum phosphate levels should be monitored for a decrease. Drugs that form sparingly soluble compounds with calcium (e.g., tetracyclines, quinolones such as ciprofloxacin and norfloxacin as well as drugs containing iron, fluoride, or estramustine) should not be taken at the same time with Nephrotor to avoid disturbed absorption of the active substance. An interval of at least two hours should elapse between the ingestion of Nephrotor and these drugs.
The susceptibility to cardioactive glycosides, and hence the risk for arrhythmia will increase in Nephrotor produces elevated serum calcium levels.
Monitoring the serum phosphate levels is needed in case if concomitant administration of aluminium hydroxide.
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