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Transient hepatitis and cholestatic jaundice have been reported.
Allergic reactions may occur, presenting as a pruritic skin rash, an erythematous skin reaction, urticaria, angioedema, anaphylaxis or eosinophilia. Coombs' test may become positive. In this event, withdrawal of co-amoxiclav and the administration of an antihistamine will suffice in most cases. Should a serious anaphylactic reaction occur, co-amoxiclav should be discontinued and the patient treated with the usual agents: Adrenaline, corticosteroids and antihistamines.
Pseudomembranous colitis has been reported.
Rarely, erythema multiforme and Stevens-Johnson syndrome have been reported.
