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Cases of overdosages are usually asymptomatic. Gastrointestinal symptoms and disturbance of the fluid and electrolyte balances may be evident. They may be treated symptomatically with attention to the water electrolyte balance. Co-amoxiclav may be removed from the circulation by haemodialysis.
During the administration of high doses of co-amoxiclav, adequate fluid intake and urinary output should be maintained to minimize the possibility of amoxicillin crystalluria.
Amoxicillin crystalluria, in some cases leading to renal failure, has been observed.
