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Use in pregnancy: Pregnancy Category D: There are no adequate and well-controlled studies in pregnanct women. If Nanoxel is used during pregnancy or if the patient becomes pregnant while receiving Nanoxel, the patient should be apprised of the potential hazard to the fetus. Women of childbearing potential should be advised to avoid becoming pregnant.
Use in lactation: It is not known whether paclitaxel is excreted in human milk. Following IV administration of carbon-14 labeled paclitaxel injection to rats on days 9-10 postpartum, concentrations of radioactivity in milk were higher than in plasma and declined in parallel with the plasma conentrations. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants, it is recommended that nursing be discontinued when receiving Nanoxel therapy.
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