Myox Dosage/Direction for Use

As with other NSAIDs, the lowest effective dose of etoricoxib should be used for the shortest possible time. The patient's need for symptomatic relief and response to therapy should be re-evaluated periodically, especially in patients with osteoarthritis.
Etoricoxib is administered orally and may be taken with or without food. The onset of action may be faster when etoricoxib is administered without food. This should be considered when rapid symptomatic relief is needed. (See Table 1.)

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Special Populations: Hepatic Impairment: Regardless of indication, in patients with mild hepatic dysfunction (Child-Pugh scores 5 to 6), a dose of 60 mg once daily should not be exceeded. In patients with moderate hepatic dysfunction (Child-Pugh scores 7 to 9), regardless of indication, the dose of 30 mg once daily should not be exceeded.
Clinical experience is limited particularly in patients with moderate hepatic dysfunction and caution is advised. There is no clinical experience in patients with severe hepatic dysfunction (Child-Pugh score ≥10); therefore, its use is contraindicated in these patients.
Renal Impairment: No dosage adjustment is necessary for patients with creatinine clearance ≥30 mL/min. The use of etoricoxib in patients with creatinine clearance <30 mL/min is contraindicated.
Elderly: No dosage adjustment is necessary for elderly patients. As with other drugs, caution should be exercised in elderly patients.