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Mycozole: Adults: For systemic candidiasis: take 400 mg on Day 1, followed by 200 mg daily for 28 days.
For cryptococcal meningitis: take 400 mg for acute and 200 mg for relapse on Day 1, followed by 200 mg daily. Duration of therapy is 10-12 weeks after CSF culture becomes negative.
For superficial mucosal candidiasis: usual dose is 50mg daily, 100mg daily may be given if necessary. Treatment usually continues for 7 to 14 days in oropharyngeal candidiasis (except in severely immunocompromised patients), for 14 days in atrophic oral candidiasis associated with dentures, and for 14 to 30 days in other mucosal candidal infections including esophagitis.
For vaginal candidiasis: 150mg by mouth as a single dose.
For dermatophytosis, pityriasis versicolor, and Candida infections: 50mg daily for up to 6 weeks.
For immunocompromised patients at risk of fungal infections: a prophylactic dose of 50 to 400mg daily.
Children: Over 4 weeks of age: 3mg/kg daily for superficial infections (a loading dose of 6mg/kg may be used on the first day if necessary), and 6 to 12mg/kg daily for systemic infections.
For prophylaxis in immunocompromised children: 3 to 12mg/kg daily.
For infants under 2 weeks of age: all these doses should be given once every 72 hours.
Aged between 2 and 4 weeks: the doses should be given every 48 hours.
Mycozole IV: It is given as a sodium containing 2 mg/mL at a rate of 5 to 10 mL/minute (300 to 600 mL/hour). In the USA, a maximum infusion rate of 100 mL/hour is recommended.
Doses for children over 4 weeks of age is 6 to 12 mg/kg daily for systemic infections. For prophylaxis in immunocompromised children, a dose of 3 to 12 mg/kg daily may be given. For infants under 2 weeks of age, all these doses should be given once every 72 hours; for those aged between 2 and 4 weeks, the doses should be given every 48 hours. A maximum dose of 400 mg daily should not be exceeded in children, or 12 mg/kg in appropriate intervals in infants.
Dosage may need to be reduced in patients with renal impairment.
