Mycin Special Precautions

Neurotoxic and nephrotoxic antibiotics may be absorbed in significant quantities from the body surface after local irrigation or application. Increased nephrotoxicity has been reported following concomitant administration of aminoglycoside antibiotics and cephalosporins. Neuromuscular blockade and respiratory paralysis may possibly occur in patients receiving anaesthetics, or neuromuscular blocking agents such as succinylcholine, tubocurarine or decamethonium, or in patients receiving massive transfusions of citrate anticoagulated blood. If neuromuscular blockade occurs, calcium salts may reverse it.
Aminoglycosides should be used with caution in patients with neuromuscular disorders such as myasthenia gravis, since these drugs may aggravate muscle weakness. Appropriate corrective therapy (electrolyte administration) should be employed if there is any evidence of hypomagnesia and hypokalemia.
Use in Pregnancy: Safety for use in pregnancy has not been established.