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Gentamicin Sulfate Injection may be given intramuscularly or intravenously. The patient's pretreatment body weight (lean body mass in case of obese patients) should be used for calculation of correct dosage. The following is recommended as a dosage guide in patients with normal renal function.
Adults: 1 to 1.7 mg/kg every 8 hours.
Children: 2.0 to 2.5 mg/kg every 8 hours.
Infants and neonates: 2.5 mg/kg every 8 hours.
Premature or full term neonates one week of age or less: 2.5 mg/kg every 12 hours.
The dosage for patients with compromised renal function undergoing hemodialysis, depends on the amount of drug removed from the blood. The amount of drug may be reduced by as much as 50% following an eight-hour dialysis. At the end of the dialysis period a dose of 1 to 1.7 mg/kg in adults and 2 mg/kg in children may be administered depending on the severity of the infection.
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