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Symptoms after overdosage with acetylcysteine have been more severe. Hypotension appears to be especially prominent, additional symptoms have included respiratory depression, haemolysis, disseminated intravascular coagulation, and renal failure, but some of these may have been due to paracetamol poisoning.
It has been suggested that generalized reactions to acetylcysteine can be treated with intravenous injection of antihistamine infusion or acetylcysteine should be temporarily stopped but can usually be restarted at a slower rate without further reaction.
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