Montair Drug Interactions

No dose adjustment is needed when montelukast is co-administered with theophylline, prednisone, prednisolone, oral contraceptives, fexofenadine, digoxin, warfarin, gemfibrozil, itraconazole, thyroid hormones, sedative hypnotics, non-steroidal inflammatory agents, benzodiazepines, decongestants and Cytochrome P450 (CYP) enzyme inducers.
Theophylline, Prednisone, and Prednisolone: Montelukast has been administered with other therapies routinely used in the prophylaxis and chronic treatment of asthma with no apparent increase in adverse reaction.
Oral contraceptives, Fexofenadine, Digoxin, and Warfarin: In drug interaction studies, the recommended clinical dose of montelukast did not have clinically important effects on the pharmacokinetics of oral contraceptive (norethindrone 1mg/ethinyl estradiol 35 mcg), digoxin, and warfarin.
Thyroid hormones, sedative hypnotics, Non-Steroidal Anti-Inflammatory Agents (NSAIDs), Benzodiazepine, and Decongestant: Although additional specific interaction studies were not performed, montelukast was used concomitantly with a wide range of commonly prescribed drugs in clinical studies without evidence of clinical adverse interactions with thyroid hormones, sedative hypnotics, non-steroidal anti-inflammatory drugs, benzodiazepines, and decongestant.
Cytochrome P450 (CYP) Enzyme Inducers: Phenobarbital, which induces hepatic metabolism, decreased the area under the plasma concentration curve (AUC) of montelukast approximately 40% following a single 10 mg-dose of montelukast. No dosage adjustment for montelukast is recommended.