Adult: The ability to eliminate fat and metabolize glucose should determine the infusion rate, and the dose should be determined individually and the choice of bag size should be made with regard to the clinical condition of the patient, the body weight and the nutritional requirements.
For patients in the normal nutritional state or under mild catabolic stresses, 0.7~1.0 g/kg (0.10~0.15 g of nitrogen/kg) daily of amino acids are administered by drip infusion. And, for patients under moderate to high catabolic stresses, 1.0~2.0 g/kg (0.15~0.30 g of nitrogen/kg) are administrated by drip infusion. Generally, 0.7~1.0 g/kg daily of total amino acids (0.10~0.15 g of nitrogen/kg) are administered by drip infusion into peripheral or central veins, which corresponds to 27~40 mL/kg of Fat Emulsion+Amino Acids with Electrolytes+Glucose (MG TNA-Peri).
Children: The ability to metabolise individual nutrients must determine the dosage. In general the infusion for small children (2-10 years) should start with a low dose i.e. 14-28 ml/kg (corresponding to 0.49-0.98 g fat/kg/day, 0.34-0.67 g amino acids/kg/day and 0.95-1.9 g glucose/kg/day) and increased by 10-15 ml/kg/day up to a maximum dosage of 40 ml/kg/day. For children over 10 years of age the dosage for adults can be applied.
The use of MG TNA-Peri is not recommended in children under 2 years of age in whom the amino acid cysteine may be considered conditionally essential.
Administration rate : The maximum administration rate for glucose is 0.25 g/kg/h. Amino acid dosage should not exceed 0.1 g/kg/h.
Fat dosage should not provide more than 0.15 g/kg/h.The administration rate should not exceed 3.7 mL/kg/hr (equivalent to 0.25 g/kg of glucose, 0.09 g/kg of amino acids, 0.13 g/kg of lipid, respectively), and the recommended infusion period is 12-24 hours or as prescribed by the physician.
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