Medixon Adverse Reactions

Adrenocortical Insufficiency: The high doses of glucocorticoids for prolonged periods can decrease endogenous corticosteroid secretion by suppressing pituitary release of corticotropin (secondary adrenocortical insufficiency).
Musculoskeletal Effect: Muscle pain or muscle weakness, atrophy of the bound protein matrix resulting in osteoporosis, vertebral compression fractures, aseptic necrosis of humeral or temporal heads, or pathology fractures of long bones.
Fluid and Electrolyte Disturbances: Sodium retention with resultant edema, potassium loss, hypokalemic alkalosis, hypertension, congestive heart failure. Ocular Effects: Posterior subcapsular cataracts increasing intraocular pressure, glaucoma, exophthalmos.
Endocrine Effects: Irregular menstruation, cushingoid state and inhibition of children's growth, decreased glucose tolerance, hyperglycemia, aggravated diabetes mellitus.
Gastrointestinal Tract Effects: Nausea, vomiting, anorexia which may result in weight loss, increasing appetite, increasing body weight, diarrhea or constipation, abdominal distention, pancreatitis, gastric irritation, ulcerative esophagitis, reactivation perforation, hemorrhage and delayed healing of peptic ulcers.
Nervous System Effects: Headache, vertigo, insomnia, increased motor activity, ischemic neuropathy, electroencephalogram abnormalities and convulsion.
Dermatological Effects: Skin atrophy, acne, increased sweating, hirsutism, facial erythema, striae, allergic dermatitis, urticaria and angioedema.
Others: Sudden discontinuation of glucocorticoid treatment will produce nausea, loss of appetite, lethargy, headache, fever, joint pain, desquamation, myalgia, weight loss and/or hypotension.