Medgyl Adverse Reactions

The adverse effects of Metronidazole are generally dose-related. The most common are gastrointestinal disturbances, especially nausea and unpleasant metallic taste; nausea is sometimes accompanied by headache, anorexia and vomiting. Diarrhea, dry mouth a furred tongue, glossitis and stomatitis may also occur. There have been rare reports of antibiotic-associated colitis associated with metronidazole.
Peripheral neuropathy, usually presenting as numbness or tingling in the extremities and epileptiform seizures are serious adverse effects on the nervous system that have been associated especially with high doses of Metronidazole or prolonged treatment. Weakness, dizziness, ataxia, drowsiness, insomnia and change in mood or mental state as depression or confusion have also been reported.
Temporary moderate leucopenia may occur in some patients receiving Metronidazole. Skin rashes and pruritus occur occasionally and anaphylaxis has been reported rarely. Other side effects including urethral discomfort and darkening of the urine. Raised liver enzyme values have occasionally been reported. Thrombophlebitis may follow the intravenous administration of Metronidazole.
Studies have shown Metronidazole to be mutagenic carcinogenic in some animals.