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In combination with fluorouracil (5-FU) for the treatment of advanced colorectal cancer.
To diminish the toxicity of methotrexate after high-dose methotrexate therapy in the management of several cancer types.
To diminish the toxicity and counteract the effects of overdosage of folic acid antagonists (methotrexate, trimetrexate, pyrimethamine, and trimethoprim).
For the treatment of megaloblastic anemias due to folate deficiency (e.g., in sprue and other nutritional deficiencies); and megaloblastic anemias of pregnancy and infancy (see Contraindications)
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