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Hypersensitivity reactions, including anaphylactoid reactions and urticaria, have been reported with both oral and parenteral leucovorin. While Folinic Acid can potentiate the toxic effects of 5-FU, potentially resulting in increased severity and frequency of certain effects, the observed toxicity is generally associated with 5-FU.
Pyrexia has occurred rarely after injections. Gastrointestinal disturbances, insomnia, agitation, and depression have been reported rarely, after high doses.
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