Liverprime HD Drug Interactions

Silibinin: Drugs metabolized by the cytochrome P450 system: Silibinin may increase the effect of drugs metabolized by the cytochrome P450 system (e.g., clopidogrel, erythromycin, fexofenadine, nifedipine, tamoxifen, and warfarin).
Hypoglycemic agents: Silibinin may decrease insulin requirements of diabetic patients with alcoholic liver cirrhosis. However, no studies suggest altered glucose metabolism in patients without liver disease. Dosage adjustment of hypoglycemic agents and monitoring of blood glucose levels may be required.
Metronidazole: When used concomitantly, silibinin may reduce the effect of metronidazole.
Oral Contraceptives: Silibinin may reduce the effectiveness of oral contraceptives.
Statins: Silibinin may have cholesterol-lowering effects in humans.
Nicotinic Acid: Carbamazepine: Nicotinic acid may decrease carbamazepine clearance.
Zinc: Bisphosphonates (alendronate, etidronate, risedronate): Concomitant intake of a bisphosphonate and zinc may decrease the absorption of both the bisphosphonate and zinc.
Cholesterol medicines: Additive effects are possible with concomitant administration; use with caution.
Copper or iron: Concomitant administration with zinc inhibits the absorption of copper and iron. Administer zinc and copper or iron as far apart as possible.
Penicillamine: Concomitant administration reduces zinc absorption.
Quinolones: Zinc decreases absorption of quinolone antibiotics (e.g., ciprofloxacin, levofloxacin, ofloxacin). Zinc salts or vitamins containing zinc should be given 2 hours after or 6 hours before antibiotics.
Tetracycline: Concomitant administration results in decreased tetracycline effectiveness. Administer tetracycline at least 2 hours before or 3 hours after zinc.
Food: Concomitant intake of caffeine or tea and zinc reduces zinc absorption. Food containing high amounts of phosphorus, calcium (dairy), or phytates (e.g., bran, brown bread) may also reduce its absorption.
Tell the doctor about all the medicines you are taking, including other supplements and herbal products.