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Pregnancy: There are no adequate data from the use of linezolid in pregnant women. Studies in animals have shown reproductive toxicity. A potential risk for humans exists. Linezolid should not be used during pregnancy unless clearly necessary i.e. only if the potential benefit outweighs the theoretical risk.
Breast-feeding: Animal data suggest that linezolid and its metabolites may pass into breast milk and, accordingly, breast-feeding should be discontinued prior to and throughout administration.
Fertility: Linezolid decreased fertility and reproductive performance of male rats at exposure levels approximately equal to those expected in humans. In dogs treated for 1 month, changes in the weights of prostate, testes and epididymis were apparent.
It is not known whether these findings have an impact on human fertility.
