Community acquired pneumonia & nosocomial pneumonia when known or suspected to be caused by susceptible gm +ve bacteria; complicated skin & soft tissue infections only when microbiological testing has established that the infection is known to be caused by susceptible gm +ve bacteria.
Reports of myelosuppression (including anaemia, leucopenia, pancytopenia & thrombocytopenia); antibiotic-associated diarrhoea & colitis, including pseudomembranous colitis & Clostridium difficile-associated diarrhoea; lactic acidosis; peripheral & optic neuropathy; convulsions. Monitor CBC wkly (including Hb levels, platelets, & total & differentiated leucocyte counts). Advise patients to report symptoms of visual impairment. Inhibits mitochondrial protein synthesis which may result in adverse events eg, lactic acidosis, anaemia & neuropathy. Not recommended for use in patients w/ underlying conditions &/or on concomitant medications which might put them at risk from MAO inhibition. Increased risk of neuropathies when used in patients currently taking or who have recently taken antimycobacterial medications for TB. May occasionally result in an overgrowth of non-susceptible organisms. Patients should be advised against consuming large amounts of tyramine rich foods. Consider glucose & Na content in patients w/ DM or other conditions associated w/ glucose intolerance, & patients on controlled Na diet, respectively. Potential for dizziness or symptoms of visual impairment while receiving treatment; advise patients not to drive or operate machinery if any of these symptoms occur. Patients w/ severe renal insufficiency, those undergoing dialysis; patients w/ severe hepatic insufficiency. No experience of administration to patients undergoing continuous ambulatory peritoneal dialysis or alternative treatments for renal failure (other than haemodialysis). Possible effects on male reproductive system are not known. Not to be used during pregnancy unless clearly necessary. Breast-feeding should be discontinued prior to & throughout administration. Not recommended in childn & adolescents (<18 yr). Elderly patients may be at greater risk of experiencing blood dyscrasias than younger patients.
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