Kidz Kit 2/Kidz Kit 3 Special Precautions

Liver functions should be checked before treatment with rifampicin and special care should be taken in alcoholic patients or those with preexisting liver disease who require monitoring during therapy. When other liver function tests are within normal limits, hyperbilirubinemia in the 1st week or moderately elevated alkaline phosphokinase are not indications to withdraw rifampicin. However, dose adjustments are necessary when there is other evidence of more serious liver toxicity.
Isoniazid should be administered with caution to patients with convulsive disorders, a history of psychosis or hepatic or renal dysfunction. Patients who are at risk of neuropathy or pyridoxine deficiency, including those who are diabetic, alcoholic, malnourished, uremic, pregnant or HIV-infected, should receive pyridoxine usually in a dose of 10 mg daily, although some have suggested using 50 mg daily. If symptoms of hepatitis eg, malaise, fatigue, anorexia and nausea develop, isoniazid should be discontinued pending evaluation.
Periodic eye examinations during isoniazid treatment have been suggested.
Liver function should be assessed before and regularly during treatment of these antituberculosis drugs.
Kidz Kit 3: Pyrazinamide should be used with caution in patients with a history of gout. Caution should be observed in patients with impaired renal function. Increased difficulty has been reported in controlling diabetes mellitus when diabetics are given pyrazinamide.