Kidz Kit 2/Kidz Kit 3 Adverse Reactions

Rifampicin is usually well tolerated. Adverse effects are more common during intermittent therapy or after restarting interrupted treatment. GI adverse effects include nausea, vomiting, anorexia and epigastric distress. Pseudomembranous colitis has been reported. Rifampicin produces transient abnormalities in liver functions. Rifampicin causes a harmless orange-red discoloration of urine and other body fluids.
Isoniazid is generally well-tolerated at currently recommended doses. Patients who are slow acetylators of isoniazid appear to have a higher incidence of some adverse effects. Also, patients whose nutrition is poor are at risk of peripheral neuritis which is one of the most common adverse effects of isoniazid. Pyridoxine may be given to prevent or treat these adverse effects. Optic neuritis has also been reported. Hematological effects reported following use of isoniazid include various anemias, agranulocytosis, thrombocytopenia and eosinophilia.
Kidz Kit 3: Hepatotoxicity is the most serious side effect of pyrazinamide therapy and its frequency appears to be dose-related. However, in its currently recommended doses, when given with isoniazid and rifampicin, the incidence of hepatitis has been reported to be <3%. Hyperuricemia commonly occurs and may lead to attacks of gout.