Enhanced effects of anticoagulants eg, warfarin. Increased risk of GI bleeding w/ antiplatelet agents & SSRIs. Increased risk of inducing serious NSAID-related adverse events w/ ASA or other NSAIDs. Increased tendency of bleeding w/ oxpentifylline. Decreased plasma clearance & vol of distribution, increased plasma concentration & half-life w/ probenecid. Reduced clearance & possibly enhanced toxicity of methotrexate. Increased plasma concentration of lithium. Reduced diuretic response to furosemide particularly in patients w/ cardiac decompensation. Reduced effect of diuretics & antihypertensive drugs. Risk of acute renal insufficiency w/ ACEIs &/or angiotensin II receptor antagonists especially in patients w/ compromised renal function & elderly. Oral administration of ketorolac trometamol after a high-fat meal resulted in decreased peak & delayed time-to-peak conc by about 1 hr.
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