Ketamax Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Ketamine HCl

Indications/Uses

Anesth agent for diagnostic & surgical procedures. Induction of anesth prior to the administration of other general anesth agents. Supplement other anesth agents.

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Dosage/Direction for Use

Surgical anesth IV 2 mg/kg w/in 30 sec after inj & lasts 5-10 min. IM 10 mg/kg w/in 3-4 min following inj & lasts 12-25 min. Sole anesth agent Induction: 0.5-2 mg/kg infusion may be maintained using a microdrip infusion of 1-3 mg/min. Intermittent inj: Initially 1-4.5 mg/kg IV or 6.5-13 mg/kg IM. Maintenance anesth: Additional ½ dose of the full induction dose. Induction agent prior to the use of other general anesth Full IV or IM dose defined in sole anesth agent & 2nd dose may be required 5-8 min following initial dose when administered IV. Supplement to anesth agents Dosage defined in sole anesth agent + another anesth agent.

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Overdosage

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Contraindications

Patient in whom a significant BP elevation would constitute a serious hazard; w/ eclampsia or pre-eclampsia.

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Special Precautions

Not be injected from the same syringe w/ barbiturates. Verbal, tactile & visual stimuli should be kept to a minimum during recovery in an attempt to reduce the risk of emergence reactions. Emergence delirium phenomena may occur during the recovery period. Avoid mechanical stimulation of the pharynx unless muscle relaxant is co-administered. Aspiration of contrast medium. Monitor cardiac function for patients w/ HTN or cardiac decompensation. Patients w/ pre-anesth elevated CSF pressure. Resp depression. Mechanical support of respiration is preferred for analeptics. Rapid administration may result in transient resp depression or apnea. Chronic alcoholism & acute alcohol intoxication. Pregnancy & lactation.

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Use In Pregnancy & Lactation

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Adverse Reactions

Hypotension, bradycardia, arrhythmia; resp depression or apnea, laryngospasm & other airway obstruction; diplopia, nystagmus, slight elevation of IOP; delirium w/ or w/o psychomotor activity (confusion & irrational behavior); tonic & clonic movements resembling seizures; anorexia, nausea, vomiting; local pain & exanthema at inj site, transient erythema or morbilliform rash, increased salivation leading to resp difficulties.

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Drug Interactions

May potentiate neuromuscular blocking effects of atacurium & tubocurarine including resp depression w/ apnoea. May lengthen the elimination t_½ & delay recovery from anesth w/ halogenated anesth which can lead to bradycardia, hypotension or decreased cardiac output. Potentiation of CNS depression &/or increased risk of developing resp depression w/ CNS depressants eg, ethanol, phenothiazines, sedating H₁ blockers or skeletal muscle relaxants. May antagonize hypnotic effect of thiopental. Increased risk of developing HTN & tachycardia w/ thyroid hormones. Increased risk of developing hypotension w/ antihypertensive. Significant reduction in seizure threshold w/ theophylline. Increased plasma conc w/ CYP3A4 inhibitors. Decreased plasma conc w/ CYP3A4 inducers.

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Storage

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Description

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Action

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MIMS Class

Anaesthetics - Local & General

ATC Classification

N01AX03 - ketamine ; Belongs to the class of other general anesthetics.

Regulatory Classification

EDD, Rx

Presentation/Packing

Form

Ketamax soln for inj 50 mg/mL

Packing/Price

10 mL x 25 × 1's

Ketamax

ketamine

Manufacturer:

Rotexmedica GmbH

Distributor:

Duopharma Trade (Phils)