Kefurox Dosage/Direction for Use

Adult: Administer 750 mg three times daily intravenously or intramuscularly. In severe cases, the dose maybe raised to 1.5 g three times daily intravenously. If necessary, frequency of administration may be raised to four times and the total daily dose is 3 to 6 g.
Children and Infant: Administer 30 to 100 mg/kg/day of Cefuroxime 3 to 4 times in divided dose by IM or IV. Usually, it is reasonable for 60 mg/kg/day.
Neonate: Administer 30 to 100 mg/kg/day 2 to 3 times in divided doses by IM or IV. During 1 week after birth, administer carefully, because serum half-life of Cefuroxime could be prolonged 3 to 5 times as many as that of adult.
Gonorrhea: Administer 1.5 g once intramuscularly or could equally administer 750 mg in both side of the breech.
Renal Failure Patient: In light renal failure case, it need not adjust dose of administration, but in mild failure case (10 to 20 mL/min in creatinine clearance.) It is enough to administer 750 mg twice a day. In severe renal failure case (below 10 mL/min in creatinine clearance), it would be reasonable to administer 750 mg/day. In hemodialysis cases, administer 750 mg more after hemodialysis. In the case of performed continuously artery and venous dialysis or high fast hematofiltration, it is reasonable to administer 750 mg twice a day and in the case of performed slow hematofiltration follow that of general renal failure.
Protection from operation after operation.
The abdominal, pelvis, orthopedic treatment: administer 1.5 g intravenously in usually inducing anesthesia and can add to 750 mg intramuscularly each time after 8 hours and 16 hours.
The heart, lung, esophagus, or blood vessel operation: administer 750 mg/day for 24 to 48 hours three times by IM, after administering 1.5 g by IV in usually including anesthesia.
Total joint replacement: Before adding liquid monomer, may use to mix Cefuroxime powder 1.5 g with each pack of methyl methacrylate cement polymer.
Meningitis: Adult: Administer 3 g three times a day by IV; Children and Infant: Administer 200 to 240 mg/kg/day 3 to 4 times in divided doses by IV. If clinical symptoms are improved or after 3 days of treatment, it could be reduced to 10 mg/kg in dose; Neonate: Initial dose is recommended 100 mg/kg/day by IV, if symptoms are improved, it could be reduced to 50 mg/kg/day in dose.
Direction for Reconstitution: In the intramuscular injection, administer it with suspension after putting the water for injection 2 mL per 250 mg.
In the intravenous injection, administer it after putting water for injection over 2 mL in 250 mg, over 6 mL in 750 mg, over 15 mL in 1.5 g.
In the infusion, administer it for 30 minutes after melting 1.5 g in water for injection 50 mL. But, for sodium bicarbonate injection solution, it is desirable not to use it as diluting agent.