Karvidol

Each film-coated tablet contains Carvedilol 6.25 mg or 25 mg.

Pharmacology: Pharmacokinetics: Carvedilol is well absorbed from the gastro-intestinal tract but is subject to considerable first pass metabolism in the liver; the absolute bioavailability is about 25%. Peak plasma concentrations occur 1 to 2 hours after administration. It has high lipid solubility. Carvedilol is more than 98% bound to plasma proteins. It is extensively metabolized in the liver, the metabolites being excreted mainly in the bile. The elimination half-life is about 6 to 10 hours. Carvedilol has been shown to accumulate in breast milk in animals.

Used in the management of hypertension, angina pectoris and heart failure.

In hypertension carvedilol is given in an initial dose of 12.5 mg once daily by mouth, increased after two days to 25 mg once daily. Alternatively, an initial dose of 6.25 mg is given twice daily, increased after one to two weeks to 12.5 mg once daily. The dose may be increased further, if necessary, at intervals of at least two weeks, to 50 mg once daily or in divided doses. A dose of 12.5 mg once daily may be adequate for elderly patients.
In angina pectoris an initial dose of 12.5 mg is given twice daily by mouth, increased after two days to 25 mg twice daily.
In heart failure 3.125 mg is given by mouth twice daily for two weeks. The dose may be then be increased, if tolerated, to 6.25 mg twice daily. The dosage should be increased as tolerated at intervals of at least two weeks to a maximum recommended dose of 25 mg twice daily for patients weighing less than 85 kg or 50 mg twice daily for patients weighing more than 85 kg.

Carvedilol is not recommended in patients with hepatic dysfunction. Acute renal failure and renal abnormalities have been reported in patients with heart failure who also suffered from diffuse vascular disease and/or renal impairment.

Skin rash, pruritus, and reversible alopecia have occurred with use of beta blockers. Other adverse effects reported include a lupus-like syndrome, male impotence, sclerosing peritonitis, and retroperitoneal fibrosis.

Store at temperatures not exceeding 30°C.

Beta-Blockers

C07AG02 - carvedilol ; Belongs to the class of alpha and beta blocking agents. Used in the treatment of cardiovascular diseases.

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