Acute hypotension, azotemia, oliguria or rarely acute renal failure in patients w/ severe CHF or underlying renal disease including renal artery stenosis. Excessive BP decrease resulting to MI or stroke in patients w/ ischemic cardiopathy or ischemic CV disease. Less effective in lowering BP in Black patients. Intravascular vol depletion. Renovascular HTN. Renal impairment & kidney transplantation. Hyperkalemia. Primary aldosteronism. Childn.
May increase serum K levels w/ K supplements & K-sparing diuretics. Increased serum conc of lithium. May lead to an increased risk of worsening of renal function w/ NSAIDs.
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