Intramol Adverse Reactions

There have been reports of bacterial keratitis associated with the use of topical ophthalmic products.
Timolol ophthalmic solution is usually well tolerated. The following adverse reactions have been reported.
Urogenital: Urination difficulties.
In addition, a variety of adverse effects have been reported with other beta-adrenergic blocking agents and may be considered potential effects of ophthalmic Timolol maleate: Digestive: Mesentric arterial thrombosis, ischaemic colitis.
Haematologic: Agranulocytosis, thrombocytopenic purpura.
Nervous System: Reversible mental depression progressing to catatonia, an acute reversible syndrome characterized by disorientation for time and place, short-term memory loss, emotional lability, slightly clouded sensorium and decreased performance on neuropsychometrics.
Allergic: Erythematous rash, fever combined with aching and sore throat, laryngospasm with respiratory distress.
Urogenital: Peyronie's disease.
There have been reports of a syndrome comprising psoriasis skin rash, conjunctivitis sicca, otitis and sclerosing serositis attributed to the beta-adrenergic receptor blocking agent, practolol. This syndrome has been reported with Timolol maleate.