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Probenecid causes an almost 2-fold reduction in clearance of paracetamol by inhibiting its conjugation with glucuronic acid. A reduction of the paracetamol dose should be considered for concomitant treatment with probenecid.
Salicylamide may prolong the elimination t½ of paracetamol.
Caution should be paid to the concomitant intake of enzyme-inducing substances.
Concomitant use of paracetamol (4 gram per day for at least 4 days) with oral anticoagulants may lead to slight variations of INR values.
In this case, increased monitoring of INR values should be conducted during the period of concomitant use as well as for 1 week after paracetamol treatment has been discontinued.
