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Pharmacology: Hyoscine Butylbromide is a quaternary ammonium agent. Hyoscine butylbromide does not readily pass the blood-brain barrier. It's a competitive antagonist of the actions of acetylcholine and other muscarinic agonists. The receptors affected are those of peripheral structures that are either stimulated or inhibited by muscarine, i.e. exocrine glands, smooth and cardiac muscles.
Pharmacokinetics: Hyoscine is readily absorbed from the gastrointestinal tract following oral doses of the hydrobromide. It is almost entirely metabolized, probably in the liver; only a small proportion of an oral dose has been reported to be excreted unchanged in the urine. It crosses the blood-brain barrier and has been stated to cross the placenta.
