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Adverse reactions associated with use of corticosteroids include: Cushing's syndrome, moon faces, supraclavicular fat pads, hirsutism, striae and acne, relative adrenocortical insufficiency particularly in time of stress due to trauma, surgery or severe illness, protein catabolism with negative nitrogen balance, electrolyte imbalance, alteration of glucose metabolism with aggravation of diabetes mellitus including hyperglycaemia and glycosuria; osteoporosis reversible only with difficulty; spontaneous fractures; activation and complication of peptic ulcer including perforation and hemorrhage; aggravation or masking of infection; increased blood pressure.
When adverse reactions occur, they are usually reversible and disappear when the hormone is discontinued.
