IM/IV inj or infusion 100-500 mg repeated 3-4 times in 24 hr. Minor surgery under general anesth 25-50 mg IV at induction. Moderate or major surgery 25-50 mg IV at induction, followed by similar dose tid 24 hr after moderate surgery & 48-72 hr after major surgery.
May mask signs of infection & enhance dissemination of infecting organism. Avoid abrupt discontinuation. Patients subjected to significant stress eg, surgery, trauma, severe illness or while being treated or w/in 1-2 yr of treatment termination. Pregnancy & lactation. Delays growth in adolescents, childn & infant.
Cushing's syndrome, moon faces, supraclavicular fat pads, hirsutism, striae & acne, relative adrenocortical insufficiency particularly in time of stress due to trauma, surgery or severe illness; protein catabolism w/ -ve nitrogen balance, electrolyte imbalance, alteration of glucose metabolism w/ aggravation of DM including hyperglycemia & glycosuria; osteoporosis; spontaneous fractures; activation & complication of peptic ulcer including perforation & hemorrhage; aggravation or masking of infection; increased BP.
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