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Interactions with cimetidine and anticoagulants have been reported.
In healthy subjects given single 500-mg doses of cefalexin and metformin, plasma metformin peak plasma concentration (Cmax) and area under the curve (AUC) increased by an average of 34% and 24%, respectively, and metformin renal clearance decreased by an average of 14%. No information is available about the interaction of cefalexin and metformin following multiple dose administration.
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