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Very rarely, lactic acidosis has been associated with Humamet treatment. It is a serious metabolic complication due to accumulation of metformin. It may also occur in association with a number of pathophysiologic conditions including diabetes mellitus, and whenever there is significant tissue hypoperfusion and hypoxemia. Lactic acidosis is characterized by elevated blood lactate levels, decreased blood pH, electrolyte disturbances with an increase in anion gap and an increased lactate/pyruvate ratio. Lactic acidosis is a medical emergency that must be treated in a hospital immediately.
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