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Concomitant administration with rifampicin or with other liver enzyme-inducing drug (eg, phenobarbital) resulted in lower plasma concentration of tropisetron HCl, therefore, the dosage should be increased in normal metabolizers (but not in poor metabolizers).
The effects on tropisetron HCl plasma levels of cytochrome P-450 enzyme inhibitors, eg cimetidine do not require dose adjustment.
As QTc prolongation has been observed in patients administered high dose of tropisetron HCl, thus care should be taken when other drugs that are likely to prolong the QT interval are taken concomitantly with tropisetron HCl.
Caution should be exercised in patients with cardiac rhythm or conduction disturbances or in patients treated with anti-arrhythmic or β-adrenergic blocking agents.
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