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Tropisetron HCl is given IV, as a slow injection or into running IV infusion or orally. Doses are calculated in terms of tropisetron base.
For the prophylaxis of nausea and vomiting associated with cytotoxic chemotherapy, a single dose equivalent to 5 mg of tropisetron may be given IV on the day of treatment shortly before chemotherapy. Subsequent doses of tropisetron 5 mg daily are given orally, at least 1 hr before food, for further 5 days.
For the treatment of postoperative nausea and vomiting, the equivalent of tropisetron 2 mg may be given by slow IV inj or by infusion over 15 min, within 2 hrs of the end of anesthesia.
For prophylaxis, the same dose may be given shortly before induction of anesthesia.
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