Apply sparingly to the affected area once or twice daily until improvement occurs. Therapy should be stopped when control is achieved. In the more responsive conditions, this may be within a few days. If longer course is necessary, it is recommended that treatment should not be continued for more than 2 weeks and the total dosage should not exceed 50 grams per week without the patient's condition being reviewed because of the potential for the drug to suppress the hypothalamus pituitary adrenal (HPA) axis. Repeated short courses of these formulations can be used to treat exacerbations. A less potent steroid should be used if continuous steroid treatment is necessary. In resistant lesions, especially with hyperkeratosis, the anti-inflammatory effects of these preparations can be enhanced, if required, by occluding the treatment area with polythene film. Overnight occlusion is generally adequate for satisfactory response. Thereafter, improvement can usually be maintained by application without occlusion. Or as directed by the physician.