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On theoretical grounds, overdosage would be expected to cause enhancement of the anti-estrogenic side effects mentioned previously.
Observations in animals show that extreme overdosage (100-200 times recommended daily dose) may produce oestrogenic effects.
There have been reports in the literature that Tamoxifen (Genzifen) given at several times the standard dose may be associated with prolongation of the QT interval of the ECG. There is no specific antidote to overdosage and treatment must be symptomatic.
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